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Tenofovir alafenamide hemifumarate

Cat. No. M20783
Tenofovir alafenamide hemifumarate Structure
Synonym:

TAF hemifumarate, GS-7340 hemifumarate

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1069
Formula C46H62N12O14P2
CAS Number 1392275-56-7
Purity >99%
Solubility DMSO 100 mg/mL
Water 50 mg/mL
Storage at -20°C
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Keywords: Tenofovir alafenamide hemifumarate, TAF hemifumarate, GS-7340 hemifumarate supplier, Reverse Transcriptase, inhibitors

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