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Temozolomide acid 

Cat. No. M27834

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Temozolomide acid  Structure

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Quality Control & Documentation
Biological Activity

Temozolomide acid is a carboxylic acid derivative of Temozolomide. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid has an activity similar to the parent compound Temozolomide with the same anticancer activity.

Chemical Information
Molecular Weight 195.14
Formula C6H5N5O3
CAS Number 113942-30-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Reena Jatyan, et al. J Control Release. Temozolomide-fatty acid conjugates for glioblastoma multiforme: In vitro and in vivo evaluation

[2] Yu-Ting Tsai, et al. J Biomed Sci. Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation

[3] Seamus Caragher, et al. Cancers (Basel). Temozolomide Treatment Increases Fatty Acid Uptake in Glioblastoma Stem Cells

[4] Jun-Hai Tang, et al. Cancer Commun (Lond). Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1-Survivin axis

[5] Ilhan Elmaci, et al. Metab Brain Dis. From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM

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  Catalog
Abmole Inhibitor Catalog




Keywords: Temozolomide acid  supplier, DNA/RNA Synthesis, inhibitors, activators

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