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Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth.
| Molecular Weight | 573.56 |
| Formula | C27H27N9O6 |
| CAS Number | 113857-87-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[3] Effrosyni Apostolidou, et al. Drugs. Treatment of acute lymphoblastic leukaemia : a new era
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