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Sulfanilamide

Cat. No. M3319
Sulfanilamide Structure
Synonym:

Sulphanilamide

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1g USD 180  USD180 In stock
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Biological Activity

Sulfanilamide is a sulfonamide antibacterial. It is a sulfonamide antibacterial. Chemically, it is a molecule containing the sulfonamide functional group attached to an aniline. As an antibiotic, it functions by competitively inhibiting (ie, by acting as a substrate analogue) enzymatic reactions involving para-aminobenzoic acid (PABA). PABA is needed in enzymatic reactions that produce folic acid which acts as a coenzyme in the synthesis of purine, pyrimidine and other amino acids.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Sprague-Dawley rats
Formulation Thoroughly mixed into the daily ration of pulverized food and compounded into pellets.
Dosages 100 mg/kg
Administration Orally taken every day
Chemical Information
Molecular Weight 172.2
Formula C6H8N2O2S
CAS Number 63-74-1
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] R N CHAUDHURI. Sulphonamides

[2] R N CHAUDHURI. Sulphonamides

[3] G HECHT. Sulfonamide

[4] S T MADSEN. PROTEIN-BINDING OF SULFONAMIDES

[5] No authors listed. J Am Med Assoc. SULFAMETHOXYPYRIDAZINE

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Keywords: Sulfanilamide, Sulphanilamide supplier, inhibitors, activators

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