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Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM. Sulfamethoxazole is most often used as a part of synergistic combination with trimethoprim in a 5:1 ratio in co-trimoxazole. Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis.
| Molecular Weight | 253.28 |
| Formula | C10H11N3O3S |
| CAS Number | 723-46-6 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] A J Salter. Trimethoprim-sulfamethoxazole: an assessment of more than 12 years of use
[2] L G Smith, et al. Trimethoprim-sulfamethoxazole
[3] No authors listed. IARC Monogr Eval Carcinog Risk Chem Hum. Sulfamethoxazole
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