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SR11237

Cat. No. M8199

All AbMole products are for research use only, cannot be used for human consumption.

SR11237 Structure
Size Price Availability Quantity
5mg USD 220  USD220 In stock
10mg USD 320  USD320 In stock
25mg USD 625  USD625 In stock
50mg USD 940  USD940 In stock
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Quality Control & Documentation
Biological Activity

SR11237 is a retinoid X receptor (RXR) selective agonist without any RAR activity that leads to the formation of RXR/RXR homodimers and activation of reporter genes containing RXR response elements. In addition, SR11237 significantly promotes reprogramming.

Chemical Information
Molecular Weight 380.48
Formula C24H28O4
CAS Number 146670-40-8
Form Solid
Solubility (25°C) DMSO: ≥28 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kun Huang, et al. Combined LXR and RXR Agonist Therapy Increases ABCA1 Protein Expression and Enhances ApoAI-Mediated Cholesterol Efflux in Cultured Endothelial Cells

[2] Whitney Kilu, et al. Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ

[3] Holly Dupuis, et al. Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model

[4] W Peter Lippert, et al. Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology

[5] G J Gendimenico, et al. A pleiotropic response is induced in F9 embryonal carcinoma cells and rhino mouse skin by All-trans-retinoic acid, a RAR agonist but not by SR11237, a RXR-selective agonist

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Keywords: SR11237 supplier, RAR/RXR, inhibitors, activators

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