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SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α.
| Molecular Weight | 620.53 |
| Formula | C32H34Cl2F3N3O2 |
| CAS Number | 1049741-03-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 11.36 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, dry, sealed |
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