Free shipping on all orders over $ 500

Sophoridine

Cat. No. M13522

All AbMole products are for research use only, cannot be used for human consumption.

Sophoridine Structure
Size Price Availability Quantity
20mg USD 80  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Sophoridine is a quinolizidine alkaloid isolated from leafs of Leguminous plant Sophora alopecuroides.L. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor drug candidate for pancreatic cancer with well-tolerated toxicity.

Chemical Information
Molecular Weight 248.36
CAS Number 6882-68-4
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Qi Wang, et al. Phytomedicine. Sophoridine: A review of its pharmacology, pharmacokinetics and toxicity

[2] Zhongwei Zhao, et al. J Cell Mol Med. Sophoridine suppresses lenvatinib-resistant hepatocellular carcinoma growth by inhibiting RAS/MEK/ERK axis via decreasing VEGFR2 expression

[3] Zhiyang Peng, et al. BMC Cancer. Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer

[4] Haroon Ur Rashid, et al. Bioorg Chem. Anti-cancer potential of sophoridine and its derivatives: Recent progress and future perspectives

[5] Rui Wang, et al. Mol Cancer Res. Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2

Related Apoptosis Products
Coenzyme Q0

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance.

C6 Ceramide

C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway.

DB2115 tertahydrochloride

DB2115 tertahydrochloride is a potent inhibitor of myeloid master regulator PU.1. DB2115 tertahydrochloride has the potential for researching cancers, including hematologic cancers.

14-3-3η Protein inhibitor 1

14-3-3η Protein inhibitor 1 is a 14-3-3η protein inhibitor with a KD of 35 µM.

Deferoxamine

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: Sophoridine supplier, Apoptosis, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.