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SMN-C2 

Cat. No. M28458

All AbMole products are for research use only, cannot be used for human consumption.

SMN-C2  Structure

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Quality Control & Documentation
Biological Activity

SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research.

Chemical Information
Molecular Weight 417.5
Formula C24H27N5O2
CAS Number 1446311-56-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Zhichao Tang, et al. Nucleic Acids Res. Recognition of single-stranded nucleic acids by small-molecule splicing modulators

[2] Jingxin Wang, et al. J Vis Exp. Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes

[3] Jingxin Wang, et al. Proc Natl Acad Sci U S A. Mechanistic studies of a small-molecule modulator of SMN2 splicing

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Keywords: SMN-C2  supplier, DNA/RNA Synthesis, inhibitors, activators

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