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(±)-SLV-319

Cat. No. M5290

All AbMole products are for research use only, cannot be used for human consumption.

(±)-SLV-319 Structure
Synonym:

(±)-Ibipinibant; BMS-646256

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 170  USD170 In stock
50mg USD 630  USD630 In stock
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Quality Control & Documentation
Biological Activity

(±)-SLV319 (Ibipinabant) is a potent and selective CB1 receptor antagonist (Ki = 7.8 nM). Exhibits 1000-fold selectivity for CB1 over CB2 receptors. Inhibits CP 55,940-induced hypotension and WIN 55,212-2-induced hypothermia in vivo.

Chemical Information
Molecular Weight 487.40
Formula C23H20Cl2N4O2S
CAS Number 362519-49-1
Solubility (25°C) 10mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chorvat RJ, et al. Bioorg Med Chem Lett. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities.

[2] Srivastava BK, et al. Bioorg Med Chem Lett. Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole.

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Keywords: (±)-SLV-319, (±)-Ibipinibant; BMS-646256 supplier, Cannabinoid, inhibitors, activators

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