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SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8.
| Molecular Weight | 213.24 |
| Formula | C12H11N3O |
| CAS Number | 31993-01-8 |
| Solubility (25°C) | DMSO 22 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] F Micheli. Curr Opin Investig Drugs. Methylphenylethynylpyridine (MPEP) Novartis
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