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Setrobuvir

Cat. No. M27748

All AbMole products are for research use only, cannot be used for human consumption.

Setrobuvir Structure
Synonym:

ANA598

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Quality Control & Documentation
Biological Activity

Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition.

Chemical Information
Molecular Weight 560.62
Formula C25H25FN4O6S2
CAS Number 1071517-39-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Abdo A Elfiky. Future Microbiol. Dual targeting of RdRps of SARS-CoV-2 and the mucormycosis-causing fungus: an in silico perspective

[2] Vrish Dhwaj Ashwlayan, et al. Saudi J Biol Sci. Insight into the biological impact of COVID-19 and its vaccines on human health

[3] Rashed Noor. Tzu Chi Med J. Antiviral drυgs against severe acute respiratory syndrome coronavirus 2 infection triggering the coronavirus disease-19 pandemic

[4] Navita L Mallalieu, et al. Clin Ther. Pharmacokinetics and pharmacodynamics of setrobuvir, an orally administered hepatitis C virus non-nucleoside analogue inhibitor

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Keywords: Setrobuvir, ANA598 supplier, DNA/RNA Synthesis, inhibitors, activators

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