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Scyllatoxin

Cat. No. M31236

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Scyllatoxin Structure

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Quality Control & Documentation
Biological Activity

Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo.

Chemical Information
Molecular Weight 3423.15
Formula C142H237N45O39S7
CAS Number 142948-19-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Matthew J K Vince, et al. Curr Protoc. Synthesis of Scyllatoxin-Based BH3 Domain Mimetics with Diverse Patterns of Native Disulfide Bonds

[2] M Margaret Harris, et al. Org Biomol Chem. Targeting anti-apoptotic Bcl2 proteins with scyllatoxin-based BH3 domain mimetics

[3] Oliver H Wittekindt, et al. Mol Pharmacol. An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel

[4] P Auguste, et al. J Biol Chem. Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization

[5] P Auguste, et al. Biochemistry. Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites

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Keywords: Scyllatoxin supplier, Potassium Channel, inhibitors, activators

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