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Satavaptan

Cat. No. M25409

All AbMole products are for research use only, cannot be used for human consumption.

Satavaptan Structure
Synonym:

SR121463

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Quality Control & Documentation
Biological Activity

Satavaptan (SR 121463) is a vasopressin V2 receptor antagonist. Satavaptan improves the control of ascites in cirrhosis. Satavaptan blocks dDAVP-mediated activation of basophilic kinases, while also blocking dDAVP-mediated inhibition of proline-directed kinases. Satavaptan affects a variety of dDAVP-mediated processes including regulation of cell-cell junctions, actin cytoskeleton dynamics, and signaling through Rho GTPases.

Chemical Information
Molecular Weight 643.79
Formula C33H45N3O8S
CAS Number 185913-78-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jennifer Ji Young Lee, et al. CMAJ. Management of hyponatremia

[2] Hugh Watson, et al. Metab Brain Dis. Satavaptan treatment for ascites in patients with cirrhosis: a meta-analysis of effect on hepatic encephalopathy development

[3] Florence Wong, et al. Gut. Satavaptan for the management of ascites in cirrhosis: efficacy and safety across the spectrum of ascites severity

[4] Florence Wong, et al. J Hepatol. Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis

[5] Pere Ginès, et al. Hepatology. Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial

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Keywords: Satavaptan, SR121463 supplier, Vasopressin Receptor, inhibitors, activators

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