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Sanguinarine

Cat. No. M3943
Sanguinarine Structure
Synonym:

Pseudochelerythrine; Sanguinarin

Size Price Availability Quantity
5mg USD 95  USD95 In stock
10mg USD 145  USD145 In stock
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Quality Control & Documentation
Biological Activity

Sanguinarine is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine induced growth inhibitory and antiproliferative effects in human prostate carcinoma cells irrespective of their androgen status. Sanguinarine may be developed as an agent for the management of prostate cancer. In vitro, Sanguinarine inhibited PP2C competitively with respect to α-casein (Ki=0.68 μM) and showed selectivity for PP2C as compared with PP1, PP2A, and PP2B.

Protocol (for reference only)
Cell Experiment
Cell lines HL60 cells
Preparation method HL60 cells (2×105 cells/ml) were treated with 1 μM sanguinarine for the indicated durations. Thereafter, cell lysates were assayed for caspase-3/7 activity using a chemiluminescent assay. kit.
Concentrations 1 μM
Incubation time 0-6 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 332.33
Formula C20H14NO4
CAS Number 2447-54-3
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ying L, et al. Acta Pharmacol Sin. Sanguinarine inhibits Rac1b-rendered cell survival enhancement by promoting apoptosis and blocking proliferation.

[2] Aburai N, et al. Biosci Biotechnol Biochem. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.

[3] Adhami VM, et al. Mol Cancer Ther. Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.

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Keywords: Sanguinarine, Pseudochelerythrine; Sanguinarin supplier, Apoptosis, inhibitors, activators


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