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Sanguinarine is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine induced growth inhibitory and antiproliferative effects in human prostate carcinoma cells irrespective of their androgen status. Sanguinarine may be developed as an agent for the management of prostate cancer. In vitro, Sanguinarine inhibited PP2C competitively with respect to α-casein (Ki=0.68 μM) and showed selectivity for PP2C as compared with PP1, PP2A, and PP2B.
| Cell Experiment | |
|---|---|
| Cell lines | HL60 cells |
| Preparation method | HL60 cells (2×105 cells/ml) were treated with 1 μM sanguinarine for the indicated durations. Thereafter, cell lysates were assayed for caspase-3/7 activity using a chemiluminescent assay. kit. |
| Concentrations | 1 μM |
| Incubation time | 0-6 hours |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 332.33 |
| Formula | C20H14NO4 |
| CAS Number | 2447-54-3 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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