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Roxithromycin (Roxl-150) is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. It prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.
| Molecular Weight | 837.07 |
| Formula | C41H76N2O15 |
| CAS Number | 80214-83-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 160 mg/mL Ethanol 160 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Marco Rossi, et al. Roxithromycin-Associated Acute Thrombocytopenia
[3] Lingli Jiang, et al. Preparation and characterization of DNA aptamers against roxithromycin
[4] A Bryskier. Roxithromycin: review of its antimicrobial activity
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