All AbMole products are for research use only, cannot be used for human consumption.
Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
Epidural administration of Ropivacaine hydrochloride monohydrate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.
Ropivacaine hydrochloride monohydrate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).
Ropivacaine hydrochloride monohydrate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.
 |
Source | Bioanalysis (2014). Figure 2. Ropivacaine hydrochloride |
| Method | cell culture | |
| Cell Lines | primary murine skeletal muscle cells | |
| Concentrations | 1.7 mM, 3.3 mM, 5.8 mM, 8.3 mM, 16.5 mM | |
| Incubation Time | 24 h | |
| Results | Treatment of myocytes with bupivacaine and ropivacaine in vitro leads to cell destruction in a doseand drug-dependent manner. |
| Cell Experiment | |
|---|---|
| Cell lines | C2C12 cell |
| Preparation method | The other part was treated with ropivacaine hydrochloride in the same concentrations (1.7 mM, 3.3 mM, 5.8 mM, 8.3 mM, 16.5 mM, respectively). After incubation for 1 and 2 hours, the LA was removed. |
| Concentrations | 1.7 mM, 3.3 mM, 5.8 mM, 8.3 mM, 16.5 mM |
| Incubation time | 1 or 2 h |
| Animal Experiment | |
|---|---|
| Animal models | Sprague-Dawley rats |
| Formulation | |
| Dosages | 0.12 ml/kg |
| Administration | i.v. |
| Molecular Weight | 328.88 |
| Formula | C17H28N2O2.HCl |
| CAS Number | 132112-35-7 |
| Solubility (25°C) | DMSO 68 mg/mL Water 40 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Animal experimental anesthetics Products |
|---|
| Orthocaine
Orthocaine is a local anesthetic agent. |
| Tolycaine
Tolycaine is an amide local anaesthetic. Tolycaine exhibits good anesthetic effects on mice. |
| Etidocaine hydrochloride
Etidocaine hydrochloride is an amino acidamide that acts as a local anesthetic with fast onset and long-acting properties. |
| Lidocaine N-ethyl bromide
Lidocaine N-ethyl bromide is a blocker of non-membrane-permeable,and Inhibits Acid-Induced Activation of Esophageal Nociceptive C Fiber Neurons. |
| MS-222
Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
