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Ro 08-2750

Cat. No. M13520

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Ro 08-2750 Structure

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Quality Control & Documentation
Biological Activity

Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM.

Chemical Information
Molecular Weight 270.24
CAS Number 37854-59-4
Solubility (25°C) DMSO 4 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lijun Wang, et al. Front Oncol. NGF Signaling Interacts With the Hippo/YAP Pathway to Regulate Cervical Cancer Progression

[2] Maria Sabater-Arcis, et al. Mol Ther Nucleic Acids. Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

[3] Chew Theng Lim, et al. Biochem J. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

[4] Gerard Minuesa, et al. Nat Commun. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

[5] Joseph K Eibl, et al. Eur J Pharmacol. Identification of novel pyrazoloquinazolinecarboxilate analogues to inhibit nerve growth factor in vitro

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Keywords: Ro 08-2750 supplier, Apoptosis, inhibitors, activators

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