Randialic acid B is a triterpenoid compound that is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and reduces psoriasis-like inflammation in vivo.
| Molecular Weight | 454.68 |
| Formula | C30H46O3 |
| CAS Number | 14021-14-8 |
| Form | Solid |
| Solubility (25°C) | N/A |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related FPR Products |
|---|
| WRW4-OH
WRW4-OH is a biological active peptide. |
| WKYMVM acetate
WKYMVM acetate is a potent agonist of the N-formyl peptide receptors FPR1 and FPRL1/2, and also activates a number of leukocyte effector functions such as chemotaxis, activation of complement receptor-3 and NADPH oxidase. |
| Trp-Lys-Tyr-Met-Val-Met-NH2
Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVm) is a synthetic peptide that is also a specific agonist for formyl peptide-like receptor 1 (FPRL1). |
| BMS-986235
BMS-986235/LAR-1219 is an FPR1-sparing FPR2-selective agonist designed to help address chronic inflammation/promote wound healing to prevent serious complications such as heart failure. |
| Boc-MLF TFA
Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations. |
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