Free shipping on all orders over $ 500

Randialic acid B

Cat. No. M10897
Randialic acid B  Structure
Size Price Availability Quantity
10mg USD 530  USD530 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Randialic acid B is a triterpenoid compound that is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and reduces psoriasis-like inflammation in vivo.

Chemical Information
Molecular Weight 454.68
Formula C30H46O3
CAS Number 14021-14-8
Form Solid
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michal Korinek, et al. Biochem Pharmacol. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo

[2] Shan-Shan Li, et al. Chin J Nat Med. Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H 2 O 2-induced myocardial cell injury

Related FPR Products
WRW4-OH

WRW4-OH is a biological active peptide.

WKYMVM acetate

WKYMVM acetate is a potent agonist of the N-formyl peptide receptors FPR1 and FPRL1/2, and also activates a number of leukocyte effector functions such as chemotaxis, activation of complement receptor-3 and NADPH oxidase.

Trp-Lys-Tyr-Met-Val-Met-NH2

Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVm) is a synthetic peptide that is also a specific agonist for formyl peptide-like receptor 1 (FPRL1).

BMS-986235

BMS-986235/LAR-1219 is an FPR1-sparing FPR2-selective agonist designed to help address chronic inflammation/promote wound healing to prevent serious complications such as heart failure.

Boc-MLF TFA

Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations.

  Catalog
Abmole Inhibitor Catalog




Keywords: Randialic acid B supplier, FPR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.