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N-Formyl-Met-Leu-Phe

Cat. No. M10468

All AbMole products are for research use only, cannot be used for human consumption.

N-Formyl-Met-Leu-Phe Structure
Synonym:

fMLP

Size Price Availability Quantity
10mg USD 90  USD90 In stock
25mg USD 140  USD140 In stock
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Biological Activity

N-Formyl-Met-Leu-Phe (fMLP) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR), which can inhibit TNF-alpha secretion. N-Formyl-Met-Leu-Phe (fMLF) acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM). N-Formyl-Met-Leu-Phe promotes osteoblastic commitment and suppresses adipogenic commitment under osteoblastic differentiation conditions. N-Formyl-Met-Leu-Phe stimulates osteogenesis is associated with increased expression of osteogenic markers and mineralization. N-Formyl-Met-Leu-Phe inhibits expression of peroxisome proliferator-activated receptor-γ1. N-Formyl-Met-Leu-Phe promotes bone formation in zebrafish and rabbits. Treatment with N-Formyl-Met-Leu-Phe results in increased expression of Runx2. Bone marrow spaces are widely formed, and connective tissue covering bone is dense, like periosteum, in N-Formyl-Met-Leu-Phe-treated calvaria.

Chemical Information
Molecular Weight 437.55
Formula C21H31N3O5S
CAS Number 59880-97-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C, sealed
References

[1] Min Kyoung Shin, et al. J Biol Chem. N-formyl-methionyl-leucyl-phenylalanine (fMLP) promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow

[2] Ling-Yu Chen, et al. J Immunol. Synergistic induction of inflammation by bacterial products lipopolysaccharide and fMLP: an important microbial pathogenic mechanism

[3] G Hetland, et al. Mol Pathol. Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro

[4] P M Lad, et al. Proc Natl Acad Sci U S A. Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin

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Keywords: N-Formyl-Met-Leu-Phe, fMLP supplier, FPR, inhibitors, activators

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