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Ranaconitine

Cat. No. M11093
Ranaconitine Structure
Size Price Availability Quantity
10mg USD 100  USD100 In stock
20mg USD 175  USD175 In stock
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Quality Control & Documentation
Biological Activity

Ranaconitine is a diterpene alkaloid isolated from A. leucostomum and is cardiotoxic.

Chemical Information
Molecular Weight 600.7
Formula C32H44N2O9
CAS Number 1360-76-5
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuanfeng Yan, et al. RSC Adv. C 18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

[2] Guang-You Jiang, et al. Fitoterapia. Fifteen new diterpenoid alkaloids from the roots of Aconitum kirinense Nakai

[3] Yang Li, et al. Nat Prod Commun. X-ray crystallographic study of ranaconitine

[4] Jun-Hui Zhou, et al. Nat Prod Res. X-ray structure study of ranaconitine hydrobromide

[5] Fuquan Yang, et al. J Chromatogr A. Preparative separation of lappaconitine, ranaconitine, N-deacetyllappaconitine and N-deacetylranaconitine from crude alkaloids of sample Aconitum sinomontanum Nakai by high-speed counter-current chromatography

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