Free shipping on all orders over $ 500


Cat. No. M30777
Ramiprilat Structure

HOE 498 diacid; Ramipril diacid

Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research.

Chemical Information
Molecular Weight 388.46
Formula C21H28N2O5
CAS Number 87269-97-4
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Marek Dziadosz, et al. Forensic Sci Med Pathol. The analysis of ramipril/ramiprilat concentration in human serum with liquid chromatography-tandem mass spectrometry - interpretation of high concentrations for the purposes of forensic toxicology

[2] J M Serrano-Rodríguez, et al. Vet J. Pharmacokinetics and pharmacodynamics of ramipril and ramiprilat after intravenous and oral doses of ramipril in healthy horses

[3] S Meisel, et al. Clin Pharmacokinet. Clinical pharmacokinetics of ramipril

[4] U Albus, et al. Biochem Pharmacol. High affinity binding of ramiprilat on isolated human glomeruli

[5] P Bünning. J Cardiovasc Pharmacol. Kinetic properties of the angiotensin converting enzyme inhibitor ramiprilat

Related ACE Products

Abz-Ser-Pro-3-nitro-Tyr is the substrate of ACE2 (angiotensin-converting enzyme-2).


Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE).


FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE).

Garcinone B

Garcinone B, a xanthone derivative, is a nature product that could be isolated from the pericarp of Mangosteen.

Spirapril hydrochloride

Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure.

Abmole Inhibitor Catalog

Keywords: Ramiprilat, HOE 498 diacid; Ramipril diacid supplier, ACE, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.