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Pyridoxine

Cat. No. M6296
Pyridoxine Structure
Synonym:

Pyridoxol, Vitamin B6, Gravidox

Size Price Availability Quantity
10mM*1mL in DMSO USD 30  USD30 In stock
50mg USD 25  USD25 In stock
100mg USD 40  USD40 In stock
500mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Pyridoxine ((Pyridoxol, Vitamin B6, Gravidox)) is a pyridine derivative. Pyridoxine acts on alzheimer's disease cell models and exerts antioxidant effects through the NRF-2 /HO-1 pathway.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models C57Bl/6 or nu/nu mice
Formulation PBS
Dosages 125 mg/kg
Administration i.v.
Chemical Information
Molecular Weight 169.18
Formula C8H11NO3
CAS Number 65-23-6
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aranda F, et al. Oncogene. Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer.

[2] Yoo DY, et al. Neurochem Res. Combination effects of sodium butyrate and pyridoxine treatment on cell proliferation and neuroblast differentiation in the dentate gyrus of D-galactose-induced aging model mice.

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Keywords: Pyridoxine, Pyridoxol, Vitamin B6, Gravidox supplier, Vitamin, inhibitors, activators


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