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Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.
Molecular Weight | 596.64 |
Formula | C31H32N8O5 |
CAS Number | 1085412-37-8 |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[5] Michele Olivieri, et al. Cell. A Genetic Map of the Response to DNA Damage in Human Cells
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