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PR-104 is a novel hypoxia-activated DNA cross-linking agent with marked activity against human tumor xenografts, both as monotherapy and combined with radiotherapy and chemotherapy.
PR-104 (80 μM; 1 hour; SiHa cells) shows greater suppression of radiation-induced DNA single-strand breaks under hypoxic than aerobic conditions. PR-104 (100 μM; 1 hour; SiHa cells) results in phosphorylation of Ser139 of histone H2AX (gH2AX). PR-104 (0.266 mmol/kg; 18 h; SiHa cells) shows activity against hypoxic cells after irradiation.
| Molecular Weight | 579.27 |
| Formula | C14H20BrN4O12PS |
| CAS Number | 851627-62-8 |
| Solubility (25°C) | DMSO 90 mg/mL Water 30 mg/mL (ultrasonic and warming) |
| Storage | -80°C, protect from light, sealed |
[2] Simone Fulda. Blood. Biomarker of sensitivity to PR-104 in leukemia
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