About 11 results found for searched term "PR-104" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M25447 | PR-104 | DNA/RNA Synthesis |
| PR-104 is a novel hypoxia-activated DNA cross-linking agent with marked activity against human tumor xenografts, both as monotherapy and combined with radiotherapy and chemotherapy. | ||
| M3229 | PR-104A | DNA/RNA Synthesis |
| PR-104A is a corresponding alcohol that is systemically converted from PR-104 and a hypoxia-targeted anticancer agent with IC50 of 153 and 60 μM for wild-type CHO AA8 under aerobic and anoxic conditions. | ||
| M3768 | Ixabepilone | Microtubule |
| Ixempra, BMS-247550, NSC 710428 | ||
| Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. | ||
| M5536 | CP-640186 HCl | Acetyl-CoA Carboxylase |
| CP-640186 Hcl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. | ||
| M15016 | Recombinant Human Eotaxin-2/CCL24 (E. coli) | Recombinant Proteins |
| C-C motif chemokine 24; CK-beta-6 | ||
| Recombinant human Eotaxin-2/CCL24 protein (E. coli) is a new CC chemokine recently discovered. It is produced by activated monocytes and T lymphocytes. Protein structure: CCL24 (VAL27-ALA104), Accession # : O00175. | ||
| M25179 | KY-1044 | Others |
| Alomfilimab; SAR 445256 | ||
| KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response. | ||
| M25496 | DRI-C21045 | TNF Receptor |
| DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively. | ||
| M29628 | VT104 | YAP |
| VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer. | ||
| M30391 | CAY10471 | Prostaglandin Receptor |
| TM30089 | ||
| CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model. | ||
| M43539 | Protein kinase inhibitor 4 | Trk |
| Protein kinase inhibitor 4 is a protein kinase inhibitor that inhibits TRK-A and ROS1 (IC50=3.0 nM and 104 nM respectively). | ||
| M43885 | Wisteria Floribunda Lectin | Others |
| WFL; WFA | ||
| Wisteria Floribunda Lectin, a phytoalexin bound to Mac-2 binding protein (M2BP) sugar chains, has low toxicity and induces cell death in Jurkat, Tall-104 and Hut-87 cell lines. In addition, WFA-positive M2BP (WFA+-M2BP) is a potent marker of liver fibrosis in chronic liver disease. | ||
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