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Placulumab

Cat. No. M25300
Placulumab Structure
Synonym:

ART621; CEP-37247; PN0621

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Quality Control & Documentation
Biological Activity

Placulumab (ART621) is an anti-TNF α domain antibody construction. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis.

Chemical Information
CAS Number 945781-29-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Placulumab, ART621; CEP-37247; PN0621 supplier, TNF Receptor, inhibitors, activators


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