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PF-4618433 

Cat. No. M27874

All AbMole products are for research use only, cannot be used for human consumption.

PF-4618433  Structure

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Quality Control & Documentation
Biological Activity

PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration.

Chemical Information
Molecular Weight 445.52
Formula C24H27N7O2
CAS Number 1166393-85-6
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Seungil Han, et al. J Biol Chem. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design

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  Catalog
Abmole Inhibitor Catalog




Keywords: PF-4618433  supplier, FAK, inhibitors, activators

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