All AbMole products are for research use only, cannot be used for human consumption.
PF-06835919 is an oral Class I clinical candidate for NAFLD/NASH, targeting ketohexokinase (KHK), an enzyme that initiates fructose metabolism.
| Molecular Weight | 356.35 |
| Formula | C16H19F3N4O2 |
| CAS Number | 2102501-84-6 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Suzanna L Attia, et al. Clin Transl Sci. Evolving Role for Pharmacotherapy in NAFLD/NASH
| Related Ketohexokinase Products |
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| KHK-IN-3
KHK-IN-3 is a ketohexokinase (KHK) inhibitor. |
| KHK-IN-2
KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM. |
| KHK-IN-1 hydrochloride
KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity. |
| KHK-IN-1
KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity. |
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