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KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity.
| Molecular Weight | 459.01 |
| Formula | C21H27ClN8S |
| CAS Number | 1303470-48-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic) Water 14.29 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | -20°C, dry, sealed |
[2] No authors listed. Carteolol
[5] S Groszkowski, et al. Pol J Pharmacol Pharm. 1-Haloacylpiperazines
| Related Ketohexokinase Products |
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KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM. |
| KHK-IN-1
KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity. |
| PF-06835919
PF-06835919 is an oral Class I clinical candidate for NAFLD/NASH, targeting ketohexokinase (KHK), an enzyme that initiates fructose metabolism. |
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