Certificate of Analysis
| Product Name: | KHK-IN-1 hydrochloride |
| Catalog Number: | M28139 |
| CAS Number: | 1303470-48-5 |
Physical and Chemical Properties
| Formula: | C21H27ClN8S |
| Molecular Weight: | 459.01 |
| Form: | Solid |
| Solubility: | DMSO 25 mg/mL (ultrasonic); Water 14.29 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage: | -20°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |