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PF-06683324

Cat. No. M8104
PF-06683324 Structure
Synonym:

PF-6683324

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Biological Activity

PF-0668324 is pan tropomyosin-related kinase (Trk) inhibitor.

Chemical Information
Molecular Weight 521.46
Formula C24H23F4N5O4
CAS Number 1799788-94-5
Solubility (25°C) DMSO: 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK.

Protein kinase inhibitor 4

Protein kinase inhibitor 4 is a protein kinase inhibitor that inhibits TRK-A and ROS1 (IC50=3.0 nM and 104 nM respectively).

TRK-IN-22

TRK-IN-22 is a TRK inhibitor.

TrkB-IN-1

TrkB-IN-1 is a potent and orally active TrkB agonist and has favorable PK properties.

  Catalog
Abmole Inhibitor Catalog




Keywords: PF-06683324, PF-6683324 supplier, Trk, inhibitors, activators


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