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Pexidartinib (PLX-3397) hydrochloride is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity.
| Molecular Weight | 454.28 |
| Formula | C20H16Cl2F3N5 |
| CAS Number | 2040295-03-0 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | 2-8°C, dry, sealed |
[2] No authors listed. Pexidartinib
[3] No authors listed. Pexidartinib
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