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Macozinone

Cat. No. M28285

All AbMole products are for research use only, cannot be used for human consumption.

Macozinone Structure
Synonym:

PBTZ169

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Quality Control & Documentation
Biological Activity

Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect.

Chemical Information
Molecular Weight 456.48
Formula C20H23F3N4O3S
CAS Number 1377239-83-2
Form Solid
Solubility (25°C) DMSO 6.4 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Angela Koryakova, et al. Microbiol Spectr. Antituberculosis Macozinone Extended-Release Tablets To Enhance Bioavailability: a Pilot Pharmacokinetic Study in Beagle Dogs

[2] Mohd Imran, et al. J Infect Public Health. An insight into the discovery, clinical studies, compositions, and patents of macozinone: A drug targeting the DprE1 enzyme of Mycobacterium tuberculosis

[3] Kaijing Guo, et al. J Pharm Biomed Anal. Characterization of degradation products of Macozinone by LC-MS/MS and elucidation of their degradation pathway

[4] Xi Chen, et al. Curr Microbiol. Identification of Mutations Associated With Macozinone-Resistant in Mycobacterium Tuberculosis

[5] Gang Zhang, et al. Acta Crystallogr C Struct Chem. Macozinone: revised synthesis and crystal structure of a promising new drug for treating drug-sensitive and drug-resistant tuberculosis

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Keywords: Macozinone, PBTZ169 supplier, Antibiotic, inhibitors, activators

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