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Osajin

Cat. No. M30155
Osajin Structure
Synonym:

CID 95168; NSC 21565

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Biological Activity

Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera with antitumor, antioxidant and anti-inflammatory activities.

Chemical Information
Molecular Weight 404.46
Formula C25H24O5
CAS Number 482-53-1
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhonglei Wang, et al. J Ethnopharmacol. Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts

[2] Giovanni Ribaudo, et al. Nat Prod Res. Photoactivated semi-synthetic derivative of osajin selectively interacts with G-quadruplex DNA

[3] Shih-Yin Huang, et al. Prostate. Osajin displays potential antiprostate cancer efficacy via impairment of fatty acid synthase and androgen receptor expression

[4] Jong-Eun Kim, et al. J Cell Biochem. Osajin Inhibits Solar UV-Induced Cyclooxygenase-2 Expression Through Direct Inhibition of RSK2

[5] Hyung-In Moon. Nat Prod Commun. Effect of osajin and pomiferin on antidiabetic effects from normal and streptozotocin-induced diabetic rats

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Keywords: Osajin, CID 95168; NSC 21565 supplier, Apoptosis, inhibitors, activators


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