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Oroxin-B

Cat. No. M4462

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Oroxin-B Structure
Size Price Availability Quantity
5mg USD 68  USD68 In stock
10mg USD 115  USD115 In stock
20mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Oroxin B (OB) is a flavonoid isolated from the traditional Chinese herb Oroxylum indicum (L.) Vent. Oroxin B (OB) can inhibit hepatoma cells by up-regulating PTEN, down-regulating COX-2, VEGF, PI3K and P-Akt, and induce early apoptosis. Oroxin B (OB) induces suppressive ER stress in malignant lymphoma cells.

Chemical Information
Molecular Weight 594.52
Formula C27H30O15
CAS Number 114482-86-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Jun-Ming Huang, et al. Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity

[2] Rui Feng, et al. A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS

[3] Nannan Li, et al. Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer

[4] Kai Niu, et al. Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC-MS/MS assay

[5] Ping Yang, et al. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy

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Keywords: Oroxin-B supplier, Apoptosis, inhibitors, activators

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