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OF-02 (Oil)

Cat. No. M22504
OF-02 (Oil) Structure
Synonym:

OF02

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Biological Activity

OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.

Chemical Information
Molecular Weight 1314.13
Formula C84H152N4O6
CAS Number 1883431-67-1
Solubility (25°C) DMSO ≥ 60 mg/mL (ultrasonic and warming and heat to 50°C)
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Oksana M Subach, et al. Int J Mol Sci. LSSmScarlet, dCyRFP2s, dCyOFP2s and CRISPRed2s, Genetically Encoded Red Fluorescent Proteins with a Large Stokes Shift

[2] Marco Nardella, et al. Foods. A Review on High-Power Ultrasound-Assisted Extraction of Olive Oils: Effect on Oil Yield, Quality, Chemical Composition and Consumer Perception

[3] Ahmet Halil Avci, et al. Molecules. Tuning the Electrochemical Properties of Novel Asymmetric Integral Sulfonated Polysulfone Cation Exchange Membranes

[4] Diana L Zuluaga, et al. Funct Integr Genomics. MicroRNAs in durum wheat seedlings under chronic and short-term nitrogen stress

[5] Sandra L Dabora, et al. Am J Hum Genet. Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients

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