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ODN TTAGGG is an inhibitory oligodeoxynucleotide (ODN) as well as a TLR9, AIM2 and cGAS antagonist with immunosuppressive activity, which inhibits the activation of the AIM2 inflammasome by competing with DNA, as well as the activation of cGAS. It can be used in the study of autoimmune diseases such as lupus erythematosus. Sequence: 5'-T-T-T-A-G-G-G-T-T-T-T-A-G-G-G-T-T-T-A-G-G-G-T-T-T-A-G-G-G-T-T-T-A-G-G-G-3'.
| Molecular Weight | 7944.30 |
| CAS Number | 1801724-76-4 |
| Form | Solid |
| Storage | -20°C, dry, sealed |
[5] Dennis Klinman et al. J Leukoc Biol. Synthetic oligonucleotides as modulators of inflammation
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