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O4I3 is a potent and selective inhibitor of the KDM5A (JARID1A) isoform of H3K4 demethylase (KDM5A IC50 = 0.15 nM vs. KDM5B/C/D IC50 = 125.2/9.76/4. 7 nM, KDM4 IC50 = 249 nM, and LSD1 IC50 >100 μM), and O4I3 can induce OCT4 expression and enhance OSKM-induced pluripotent stem cells (iSCs) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter, thus effectively inducing OCT4 expression and improving OSKM-induced reprogramming efficiency of human primary fibroblast pluripotent stem cells (iPSC) (50 nM). In addition, O4I3 promoted hPSC homeostasis and inhibited cell differentiation, and increased hPSC survival by 4-fold at a low concentration of 10 nM compared with Rock inhibitor Y-27632 at 10 μM.
Molecular Weight | 222.29 |
Formula | C15H14N2 |
CAS Number | 88965-00-8 |
Form | Solid |
Solubility (25°C) | DMSO 2 mg/mL |
Storage | 4°C |
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