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O4I3

Cat. No. M54719

All AbMole products are for research use only, cannot be used for human consumption.

O4I3 Structure
Size Price Availability Quantity
1g USD 50  USD50 In stock
5g USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

O4I3 is a potent and selective inhibitor of the KDM5A (JARID1A) isoform of H3K4 demethylase (KDM5A IC50 = 0.15 nM vs. KDM5B/C/D IC50 = 125.2/9.76/4. 7 nM, KDM4 IC50 = 249 nM, and LSD1 IC50 >100 μM), and O4I3 can induce OCT4 expression and enhance OSKM-induced pluripotent stem cells (iSCs) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter, thus effectively inducing OCT4 expression and improving OSKM-induced reprogramming efficiency of human primary fibroblast pluripotent stem cells (iPSC) (50 nM). In addition, O4I3 promoted hPSC homeostasis and inhibited cell differentiation, and increased hPSC survival by 4-fold at a low concentration of 10 nM compared with Rock inhibitor Y-27632 at 10 μM.

Chemical Information
Molecular Weight 222.29
Formula C15H14N2
CAS Number 88965-00-8
Form Solid
Solubility (25°C) DMSO 2 mg/mL
Storage 4°C
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Keywords: O4I3 supplier, Cell Culture, inhibitors, activators

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