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Norstictic acid 

Cat. No. M30307
Norstictic acid  Structure
Size Price Availability
1mg USD 510  USD510 3-4 Weeks
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Quality Control & Documentation
Biological Activity

Norstictic acid is a potent and selective allossteric transcriptional regulator. Norstictic acid shows anticancer activity. Norstictic acid shows antioxidant activity and antimicrobial activity.

Chemical Information
Molecular Weight 372.28
Formula C18H12O9
CAS Number 571-67-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Julie M Garlick, et al. J Am Chem Soc. Norstictic Acid Is a Selective Allosteric Transcriptional Regulator

[2] Isabel Ureña-Vacas, et al. Planta Med. Lichen Depsidones with Biological Interest

[3] Hassan Y Ebrahim, et al. Phytother Res. Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met

[4] Branislav Ranković, et al. Int J Mol Sci. Biological activities of Toninia candida and Usnea barbata together with their norstictic acid and usnic acid constituents

[5] Turgay Tay, et al. Z Naturforsch C J Biosci. Evaluation of the antimicrobial activity of the acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid, norstictic acid, and protocetraric acid constituents

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