Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer.
Molecular Weight | 787.8 |
Formula | C39H49NO16 |
CAS Number | 1404-15-5 |
Form | Solid |
Storage | Powder -20°C |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] L D Williams, et al. Proc Natl Acad Sci U S A. Structure of nogalamycin bound to a DNA hexamer
[3] M Egli, et al. Biochemistry. DNA-nogalamycin interactions
[4] L H Li, et al. Pharmacol Ther. The biochemical pharmacology of nogalamycin and its derivatives
[5] P F Wiley, et al. J Am Chem Soc. Structure of nogalamycin
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