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BOLD-100

Cat. No. M29074

All AbMole products are for research use only, cannot be used for human consumption.

BOLD-100 Structure
Synonym:

NKP-1339; IT-139; KP-1339

Size Price Availability
10mg USD 285  USD285 Out of stock
50mg USD 770  USD770 Out of stock
100mg USD 1155  USD1155 Out of stock
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Biological Activity

BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu.

Chemical Information
Molecular Weight 502.14
Formula C14H12Cl4N4NaRu
CAS Number 197723-00-5
Form Solid
Solubility (25°C) DMSO ≥ 59 mg/mL
Storage 4°C, dry, sealed
References

[1] Brian J Park, et al. Cancers (Basel). Utilization of Cancer Cell Line Screening to Elucidate the Anticancer Activity and Biological Pathways Related to the Ruthenium-Based Therapeutic BOLD-100

[2] Elia Ranzato, et al. Cancers (Basel). ER Stress Response and Induction of Apoptosis in Malignant Pleural Mesothelioma: The Achilles Heel Targeted by the Anticancer Ruthenium Drug BOLD-100

[3] Dina Baier, et al. Pharmaceutics. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation

[4] Benjamin Neuditschko, et al. Angew Chem Int Ed Engl. Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum

[5] Suzanne Bakewell, et al. Cancers (Basel). Inhibition of DNA Repair Pathways and Induction of ROS Are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer

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Keywords: BOLD-100, NKP-1339; IT-139; KP-1339 supplier, DNA/RNA Synthesis, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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