Free shipping on all orders over $ 500

BOLD-100

Cat. No. M29074

All AbMole products are for research use only, cannot be used for human consumption.

BOLD-100 Structure
Synonym:

NKP-1339; IT-139; KP-1339

Size Price Availability
10mg USD 285  USD285 Out of stock
50mg USD 770  USD770 Out of stock
100mg USD 1155  USD1155 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu.

Chemical Information
Molecular Weight 502.14
Formula C14H12Cl4N4NaRu
CAS Number 197723-00-5
Form Solid
Solubility (25°C) DMSO ≥ 59 mg/mL
Storage 4°C, dry, sealed
References

[1] Brian J Park, et al. Cancers (Basel). Utilization of Cancer Cell Line Screening to Elucidate the Anticancer Activity and Biological Pathways Related to the Ruthenium-Based Therapeutic BOLD-100

[2] Elia Ranzato, et al. Cancers (Basel). ER Stress Response and Induction of Apoptosis in Malignant Pleural Mesothelioma: The Achilles Heel Targeted by the Anticancer Ruthenium Drug BOLD-100

[3] Dina Baier, et al. Pharmaceutics. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation

[4] Benjamin Neuditschko, et al. Angew Chem Int Ed Engl. Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum

[5] Suzanne Bakewell, et al. Cancers (Basel). Inhibition of DNA Repair Pathways and Induction of ROS Are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer

Related DNA/RNA Synthesis Products
Dencatistat

Dencatistat (P115) is an inhibitor of Cytidine Triphosphate Synthase 1 (CTPS1) with an IC50 value of ≤ 0.1 μM.

Antipain dihydrochloride

Antipain dihydrochloride is a protease inhibitor. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride also restricts uterine DNA synthesis and function in mice.
Tetrahydrouridine

Tetrahydrouridine (THU) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine.
Crisnatol

Crisnatol (BWA770U) is a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells. Crisnatol (BWA770U) is also an orally active and anticancer agent.
Caf1-IN-1

Caf1-IN-1 is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM.
  Catalog
Abmole Inhibitor Catalog




Keywords: BOLD-100, NKP-1339; IT-139; KP-1339 supplier, DNA/RNA Synthesis, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.