About 2 results found for searched term "BOLD-100" (0.208 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29074 | BOLD-100 | DNA/RNA Synthesis |
| NKP-1339; IT-139; KP-1339 | ||
| BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu. | ||
| M30607 | BOLD-100 free base | HSP |
| NKP-1339 free base; IT-139 free base; KP-1339 free base | ||
| BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. | ||
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