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Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family. Nicotinic acid (Niacin) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Nicotinic acid (Niacin) is also used in the study of cardiovascular diseases.
Niacin (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism. Niacin (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation.
Niacin (3-300 mg/kg; subcutaneous injection; once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice.
| Molecular Weight | 123.11 |
| Formula | C6H5NO2 |
| CAS Number | 59-67-6 |
| Solubility (25°C) | DMSO 30 mg/mL Water 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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