Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family. Nicotinic acid (Niacin) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Nicotinic acid (Niacin) is also used in the study of cardiovascular diseases.
Niacin (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism. Niacin (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation.
Niacin (3-300 mg/kg; subcutaneous injection; once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice.
Molecular Weight | 123.11 |
Formula | C6H5NO2 |
CAS Number | 59-67-6 |
Solubility (25°C) | DMSO 30 mg/mL Water 10 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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