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NDI-091143

Cat. No. M9587
NDI-091143 Structure
Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 120  USD120 In stock
25mg USD 250  USD250 In stock
50mg USD 450  USD450 In stock
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Quality Control
Biological Activity

NDI-091143 is a novel potent inhibitor of human ATP-citrate lyase with an IC50 of 2.1 nM (ADP-Glo assay). NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain. The thermal shift data are consistent with limited proteolysis experiments using full-length ACLY, in which NDI-091143 together with Mg-ATP provided the greatest protection against digestion by chymotrypsin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 453.84
Formula C20H14ClF2NO5S
CAS Number 2375840-87-0
Purity >98.5%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Carlotta Granchi. Trends Pharmacol Sci. Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase

[2] Jia Wei, et al. Nature. An Allosteric Mechanism for Potent Inhibition of Human ATP-citrate Lyase

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Keywords: NDI-091143 supplier, ATPase, inhibitors

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