About 1 result found for searched term "NDI-091143" (0.14 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9587 | NDI-091143 | ATPase |
| NDI-091143 is a novel potent inhibitor of human ATP-citrate lyase with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate. | ||
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