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Naphthazarin

Cat. No. M13513

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Naphthazarin Structure
Synonym:

DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone

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Quality Control & Documentation
Biological Activity

Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects.

Chemical Information
Molecular Weight 190.15
CAS Number 475-38-7
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aneta Jezierska, et al. Int J Mol Sci. Non-Covalent Forces in Naphthazarin-Cooperativity or Competition in the Light of Theoretical Approaches

[2] Chuanjie Guo, et al. Pharmacol Res. Pharmacological properties and derivatives of shikonin-A review in recent years

[3] Małgorzata Rudnicka, et al. Int J Mol Sci. Effects of Naphthazarin (DHNQ) Combined with Lawsone (NQ-2-OH) or 1,4-Naphthoquinone (NQ) on the Auxin-Induced Growth of Zea mays L. Coleoptile Segments

[4] Omar Aljanadi, et al. Basic Clin Pharmacol Toxicol. Stimulation of Suicidal Erythrocyte Death by Naphthazarin

[5] Seon Young Choi, et al. J Neurosci Res. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model

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Keywords: Naphthazarin, DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone supplier, Apoptosis, inhibitors, activators

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