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NAE-IN-M22 is a potent, selective, and reversible inhibitor of NEDD8-activating enzyme (NAE) in the micromolar range. In addition, NAE-IN-M22 inhibits the growth of various cancer cells and induces apoptosis in A549 cells.
| Molecular Weight | 363.32 |
| Formula | C20H24Cl2N2 |
| CAS Number | 864420-54-2 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NEDD8-activating Enzyme Products |
|---|
| ZM223
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active. |
| ZM223 hydrochloride
ZM223 hydrochloride is a potent, orally active, non-covalent NEDD8 activating enzyme (NAE) inhibitor. |
| TAS4464 hydrochloride
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM. |
| Pevonedistat hydrochloride
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC50 of 4.7 nM. |
| TAS4464
TAS4464 is a highly selective inhibitor of NEDD8 activated enzyme (NAE),IC50 The value is 0.955 nM. |
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