MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
| Molecular Weight | 594.86 |
| Formula | C26H16ClF9N2O2 |
| CAS Number | 2289690-31-7 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related c-Myc Products |
|---|
| Omomyc
Omomyc is a cell-penetrating peptide derived from the bHLH structural domain of Myc. When expressed in cells, Omomyc inhibits C-Myc-mediated transcription and suppresses cell proliferation.Omomyc competes with C-Myc for binding to Max, resulting in the formation of the Omomyc/Max complex, which competes with the endogenous c-Myc/Max heterodimer and ultimately inhibits transcriptional activation resulting in Myc target genes involved in proliferation and metabolism. |
| MDEG-541
MDEG-541 is a potent MYC-MAX degrader. |
| c-Myc inhibitor 11
c-Myc inhibitor 11 is a c-MYC inhibitor (pEC50: 6.4). |
| c-Myc inhibitor 12
c-Myc inhibitor 12 is an inhibitor of c-Myc with a pEC50 of 6.4. |
| m-Se3
m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
